The and will square off against the and on Friday at 7:10 p.m. ET, in the first game of a three-game series at Fenway Park. The White Sox are listed as +221 moneyline underdogs in this matchup against the Red Sox (-272). Boston is favored on the run line (-1.5). A 9-run over/under is set in the game. Here is everything you need to know from a betting perspective on the Red Sox-White Sox game, regarding the run line, moneyline and total, plus expert picks. Red Sox vs. Mets Highlights | MLB Red Sox vs. White Sox Game Information Odds When: Friday, September 6, 2024 at 7:10 p.m. ET Where: Fenway Park in Boston, Ma sachusetts How to Watch on TV: NESN Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Red Sox -272 +221 9 -103 -118 -1.5 -134 +112 Red Sox vs. White Sox Prediction Score Prediction: Red Sox 6, White Sox 4 Total Prediction: Over 9 runs Win Probabilities: Red Sox 60%, White Sox 40% Red Sox vs. White Sox Betting Insights This season, the Red Sox have won 36 out of the 68 games, or 52.9%, in which they've been favored. Boston has not entered a game this season with shorter moneyline odds than -272. The Red Sox have a 73.1% chance to win this game based on the implied probability of the moneyline. The White Sox have won in 28, or 21.1%, of the 133 contests they have been named as odds-on underdogs this year. Chicago has a win-lo s record of 3-17 when favored by +221 or worse by bookmakers this year. The White Sox have an implied victory probability of 31.2% according to the moneyline set by oddsmakers for this matchup. Red Sox Recent Betting Performance The Red Sox went 3-3 acro s the six games they were a moneyline favorite in their last 10 matchups. In their last 10 matchups (all 10 of them had set totals), the Red Sox and their Rondae Hollis-Jefferson Jersey opponents combined to hit the over four times. The Red Sox are 4-6-0 against the spread over their past 10 games. Red Sox Recent Stats Stat Avg/Total Record 3-7 Runs Per Game 2.7 HR 7 ERA 3.87 K/9 8.6 Red Sox Player Insights Jarren Duran leads the Red Sox with a .294 batting average. Of all hitters in the majors, Duran is 42nd in homers and 41st in RBI. Duran brings a hitting streak of six games into this game. During his last 10 outings he is hitting .359 with four doubles, three home runs, two walks and seven RBI. has shown his power as he paces his team with 28 home runs and 81 RBI. Devers is 19th in home runs and 25th in RBI among all MLB hitters this season. has 20 doubles, five triples, 14 home runs and 15 walks while hitting .253. Tyler O'Neill has 16 doubles, 25 home runs and 45 walks while batting .255. O'Neill is riding a four-game hitting streak into this one. During his last five outings he is batting .267 with a home run, four walks and an RBI. White Sox Recent Betting Performance In 10 games as underdogs over the last 10 matchups, the White Sox have a record of 1-9. In their last 10 games with a total, the White Sox and their opponents have failed to hit the over seven times. The White Sox have three wins against the spread in their last 10 chances. White Sox Recent Stats Stat Avg/Total Record 1-9 Runs Per Game 2.3 HR 5 ERA 4.60 K/9 9.6 White Sox Player Insights Andrew Vaughn paces the White Sox with 16 long balls and runs batted in, driving in 60. Among all batters in MLB, Vaughn ranks 97th in home runs and 81st in RBI. Andrew Benintendi is batting .217 with 19 doubles, 15 home runs and 36 walks. Benintendi is 108th in homers and 129th in RBI among all MLB batters this year. paces the White Sox's lineup with a .244 batting average. Lopez is batting .241 with 12 doubles, three triples, a home run and 34 walks. White Sox vs. Orioles Highlights | MLB Isaiah Rider Jr. Jersey